妊娠は細胞内感染に対する抗体保護を可能にします
John J Erickson1,2, Stephanie Archer-Hartmann3, Alexander E Yarawsky4
1Department of Pediatrics, Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Nature
|June 8, 2022
まとめ
新生児のListeria monocytogenesのような細胞内感染症に対する保護を可能にします. この適応は,脱酸化IgGとCD22受容体を通して新生児の免疫を強化します.
科学分野:
- 免疫学
- 微生物学
- 新生児の健康
背景:
- 適応免疫は伝統的に抗体に細胞外的役割,T細胞に細胞内的な役割を与えます.
- 細胞内病原体に対する新生児の感受性は,母体の抗体への依存と関連しています.
- 妊娠には 免疫学的適応が伴い 母親と胎児の健康に影響します
研究 の 目的:
- 細胞内病原体に対する保護を与える妊娠誘発抗体変異を調査する.
- 母親の抗体が新生児を細胞内感染症から守るメカニズムを解明する.
- 新生児の免疫における抗体脱酸化と特定の受容体の役割を理解する.
主な方法:
- Listeria monocytogenes感染のマウスモデルを使用した.
- 妊婦と処女マウスから受けた被動抗体移植.
- 抗体機能におけるシアル酸アセチルエストラーゼとCD22の役割を調査した.
- B細胞のIL-10産生と新生児の感染感受性を評価した.
主要な成果:
- 新生児のマウスのリステリア・モノサイトゲネスに対する 妊娠による母体IgGの変異は保護を与えました.
- シアリック酸アセチルエステラーゼによるIgGの脱酸化は,保護機能の獲得に不可欠でした.
- CD22受容体経由によるデアセチル化IgGによる保護により,B細胞のIL-10の産生を抑制する.
- 母親のB細胞は抗体生成には不可欠でしたが,保護機能の獲得には不可欠ではありませんでした.
結論:
- 妊娠による抗体脱酸化は,細胞内病原体に対する保護を提供します.
- このメカニズムは,B細胞の反応を調節することによって,新生児の免疫を強化します.
- 母親と胎児の二重体は 宿主の防御に特異な適応を備えた 統一免疫ユニットとして機能します
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