1型および2型糖尿病における左側退行性弁疾患

Araz Rawshani^1,2, Naveed Sattar³, Darren K McGuire⁴

¹Department of Molecular and Clinical Medicine (Araz Rawshani, O.W., U.S., J.B., G.B., E.O., A. Rosengren, Aidin Rawshani), University of Gothenburg, Sweden.

Circulation

|June 9, 2022

まとめ

糖尿病は1型と2型の両方の患者で心臓弁の狭窄のリスクを高めます. 2型糖尿病では,弁反発のリスクを低下させますが,最適なリスクファクター制御は,狭窄症のリスクを排除しません.

科学分野:

心臓病科
内分泌学
公衆衛生

背景:

糖尿病と弁性心疾患の関係,特にリスクファクターの管理に関して,さらなる調査が必要である.
糖尿病患者と一般の集団の両方で観察された弁結末の発生率の増加.

研究の目的:

糖尿病と心臓弁疾患との関連を調査する
糖尿病患者の弁結末に対する心血管リスク因子制御の影響を調べる.

主な方法:

スウェーデン国立糖尿病登録簿から715,143人の糖尿病患者を対照群2,732,333人と比較した大規模なコホート研究.
傾向を分析し,糖尿病をリスク因子として評価するために発生率とコックス回帰を用いた.
糖尿病患者のサブグループ内で別々に評価された危険因子.

主要な成果:

1型および2型糖尿病の患者は,静脈弁の損傷のリスクが増加します.
2型糖尿病は,対照群と比較して,大動脈およびミトラル吐のリスクが低下している.
リスクファクターのコントロールがほぼ最適であった場合でも,糖尿病,特に1型糖尿病の患者は,弁狭窄のリスク比率が著しく高かった.

結論:

糖尿病,特に1型は,狭窄弁の病変のリスクを高めます.
2型糖尿病は,弁反発のリスクの低下と関連しています.
糖尿病患者の心臓血管リスク因子の有効な制御は,弁狭窄のリスクを完全に軽減しません.

キーワード:

大動脈弁の病気糖尿病糖尿病流行病学についてミトラル弁の病気リスク要因

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