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Updated: Sep 20, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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ゲノムスケールによる情報豊富なゲノタイプ・フェノタイプのマッピング Perturb-seq

Joseph M Replogle1, Reuben A Saunders2, Angela N Pogson3

  • 1Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94158, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Cell
|June 10, 2022
PubMed
まとめ

この研究では,ゲノムスケールの Perturb-seq を使って,何百万ものヒト細胞の遺伝子機能をマッピングしています. 細胞過程における新しい遺伝子の役割を明らかにし,アヌプロイドとミトコンドリアの調節に関する洞察を明らかにします.

キーワード:
CRISPRについてインテグレーター・コンプレックスパートルブ=セク細胞生物学染色体不安定性遺伝子スクリーニングゲノタイプ-フェノタイプマップミトコンドリアゲノムのストレス反応単細胞RNAシーケンシング

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