運動によって誘発される代謝物質で,食事と肥満を抑制する
Veronica L Li1,2,3,4, Yang He5, Kévin Contrepois6,7,8
1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Nature
|June 15, 2022
まとめ
運動は食欲と肥満を抑制する代謝物であるN-ラクトイルフェニララニンの生成を刺激します この保存された分子は 種間の食生活と 系統的なエネルギーバランスを 制御します
科学分野:
- 代謝に関する研究
- 運動生理学
- 分子生物学
背景:
- 運動は肥満や心臓代謝疾患から身を守ります
- 運動の代謝効果の背後にある 正確な分子メカニズムは 完全に理解されていません
研究 の 目的:
- 運動による代謝効果の分子媒介を特定する.
- N-ラクトイル-フェニララニン (Lac-Phe) が食生活と体重を調節する役割を調査する.
主な方法:
- 運動に対するN-ラクトイルフェニララニン (Lac-Phe) の生成を調査した.
- 食事による肥満マウスの薬理学的および遺伝的アプローチを用いて,ラックフェの効果を評価した.
- 人間と競走馬のLac-Pheレベルを測定した.
主要な成果:
- 運動は様々な細胞のN- ラクトイルフェニララニン (Lac- Phe) の生成を刺激する.
- ラックフェの薬理学的増加は,マウスの食物摂取と肥満を減少させた.
- Lac-Phe生物合成の遺伝的消去は 運動後の食物の摂取量と肥満を増加させた.
- 身体活動の後の人と競走馬でLac-Phe濃度の上昇が観察されました.
結論:
- N- ラクトイルフェニララニン (Lac- Phe) は保存され,運動誘発性代謝物質で,栄養と肥満を抑制する.
- 身体活動の分子エフェクタとして作用し,全身のエネルギーバランスに影響を与えます.
- この発見は 肥満や代謝障害の管理に 新しい目標を提供します
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