液体/蒸気界面でのアニゾトロピク分子組織は,ポリモルフ選択による結晶核化を促進する

Xin Yao¹, Qitong Liu², Bu Wang²

¹School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

Journal of the American Chemical Society

|June 23, 2022

まとめ

液体表面結晶は12倍の速さで異なるポリモルフを選びます分子パッキングによって引き起こされるこの表面効果は,インターフェースを持つシステムにおける結晶化の制御に不可欠である.

科学分野:

物理化学
材料科学
結晶化科学

背景:

液体の表面における分子組織と動態は,大体とは異なる.
これらのインターフェイスの違いは,結晶の核形成とポリモルフィズムに影響を与えます.
表面効果が核形成に与える正確な影響は,まだ十分に理解されていない.

研究の目的:

液体の表面が結晶の核形成と多形性選択に及ぼす影響を調査し,定量化する.
表面強化核化の背後にあるメカニズムを解明する.
表面誘発結晶を制御する方法を探求する.

主な方法:

純粋な液体のd-アラビトールで核化研究.
質量で表層の核化率を測った.
温度と第2の表面活性成分の影響について調べました
インターフェースの分子包装を分析した.

主要な成果:

d- アラビトールの表面核化は,大量と比較して12度増加した.
異なるポリモルフは表面で選択されました.
表面効果は冷却によって強まった.
表面活性成分が表面核増強を阻害した.

結論:

インターフェースのアニゾトロプ的分子パッキングは,結晶の核化を著しく強化し,変化させます.
表面誘発結晶は温度と添加物によって制御できます.
発見は,ナノドロップレットや大気中の水のような重要なインターフェースを持つシステムにおける結晶化に関連しています.

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