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Updated: Sep 6, 2025

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腫瘍死滅因子 (TNF) は,リバース電子輸送によって結核における病原性ミトコンドリアROSを誘発する

Francisco J Roca1, Laura J Whitworth1,2, Hiran A Prag3

  • 1Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.

Science (New York, N.Y.)
|June 23, 2022
PubMed
まとめ

過剰な腫瘍死因 (TNF) は,ミトコンドリアの活性酸素種 (mROS) を増加させ,結核の感受性を誘発する. コンプレックスI阻害剤であるメトホルミンは,mROSとマクロファージの死滅を阻害し,結核の治療の可能性を示唆する.

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