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Updated: Sep 6, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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銅ヘテロスコーピオネートに基づく人工メタロ酵素は,分子内カルベンの挿入によるsp3 C-H機能化を可能にします

Corentin Rumo1, Alina Stein1, Juliane Klehr2

  • 1Department of Chemistry, University of Basel, Basel CH-4058, Switzerland.

Journal of the American Chemical Society
|June 24, 2022
PubMed
まとめ

人工金属酵素は,sp3 C-H結合の選択的修正を可能にします. ストレプタビディンの銅複合体はカルベンの挿入を触媒化し,遺伝的最適化後にエナチオセレクティブの乳酸形成を生成する.

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