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ストロマ細胞におけるYAP/TAZ活動は,cGAS-STINGを制御することによって老化を防止する

Hanna Lucie Sladitschek-Martens1, Alberto Guarnieri1, Giulia Brumana1

  • 1Department of Molecular Medicine, University of Padua, Padua, Italy.

Nature
|June 29, 2022
PubMed
まとめ

YAP/TAZのメカニカル伝達が低下すると,cGAS-STINGの先天性免疫シグナルが活性化され,老化を誘発する. YAP/TAZの維持やSTINGの抑制は,老化を制限し,健康的な老化を改善する可能性があります.

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