腸内ウイルスは唾液腺で複製し,唾液を通して感染します
S Ghosh1, M Kumar1, M Santiana1
1Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Nature
|June 29, 2022
まとめ
腸内ウイルスは唾液腺に感染し,唾液を通して複製し,拡散します. この発見は糞口以外の新たな感染経路を明らかにし,母親から乳児への感染と衛生上の戦略に影響を与えています.
科学分野:
- ウイルス学
- 胃腸内科
- 免疫学
背景:
- 腸内ウイルスは伝統的に経口経路で感染する.
- 唾液腺は腸内ウイルス複製の主要部位とは考えられませんでした.
- 狂犬病のようなウイルスは SG に感染し,唾液で伝染します.
研究 の 目的:
- 腸内ウイルスが唾液腺に感染し複製するかどうかを調べる
- 腸内ウイルスの新しい感染経路を特定する.
- 唾液腺の感染が 病気の蔓延と制御に及ぼす影響を調べる
主な方法:
- SG由来球体と細胞系が腸内ウイルスに感染する.
- SGと腸のウイルスタイターの定量化
- 唾液にウイルスを放出する分析
- 唾液や牛乳による乳児から母への感染の調査
主要な成果:
- 腸内ウイルスは 唾液腺を生産的で持続的に感染します
- SGのウイルスの位数は腸内位数と同等でした.
- entericウイルスは唾液に放出され,新しい感染経路を確立します.
- 赤ちゃんの唾液は 腸内ウイルスを 母親の乳腺に伝達し 腸内-乳腺軸を回避します
結論:
- 唾液腺は腸内ウイルスの重要な複製部位として機能する.
- 唾液は腸内ウイルス感染の 新しく重要な経路です
- この発見により,唾液によるウイルスの感染を緩和するために,衛生と予防戦略を改定する必要がある.
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