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Updated: Sep 6, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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ハイドラジン形成酵素のユニークな基板から生成された天然のダイヒドロピルダジノン基板

Kenichi Matsuda1,2, Kuga Arima1, Satoko Akiyama1

  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo 060-0812, Japan.

Journal of the American Chemical Society
|June 30, 2022
PubMed
まとめ

研究者達は,希少な窒素-窒素結合と二水ピリダジノン環を特徴とする,新しい天然産物,アクチノピリダジノンAとBを発見した. この発見により 細菌の生体合成と 自然産物の多様性に関する理解が 広がりました

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Cyanohydrins are compounds that contain –CN and –OH groups on the same carbon atom. They are formed by the nucleophilic addition of the cyanide ions to the carbonyl group. Cyanide ions are highly basic and nucleophilic and can be generated from HCN under aqueous conditions. However, since HCN is a weak acid, the number of cyanide ions generated is very small. Hence, a small amount of base or KCN/NaCN is added to HCN to increase the concentration of the cyanide ions in the reaction...
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