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Updated: Sep 5, 2025

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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スーパーエンハンスターハイパーミューテーションはB細胞リンパ腫における腫瘍遺伝子の発現を変化させる

Elodie Bal1, Rahul Kumar1,2, Mohammad Hadigol3

  • 1Institute for Cancer Genetics, Columbia University, New York, NY, USA.

Nature
|July 6, 2022
PubMed
まとめ

拡散型B細胞リンパ腫 (DLBCL) は,遺伝子調節に不可欠なスーパーエンハンサーの変異を伴う. これらの変異はBCL6,BCL2,CXCR4などのコゲンに影響を及ぼし,この一般的なノンホッジキンリンパ腫の新たな治療標的を提供している.

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