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関連する概念動画

Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

2.2K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
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Indirect Motor Pathways01:22

Indirect Motor Pathways

1.6K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.6K
Direct Motor Pathways01:11

Direct Motor Pathways

2.4K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.4K

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関連する実験動画

Updated: Sep 5, 2025

Force and Position Control in Humans - The Role of Augmented Feedback
06:31

Force and Position Control in Humans - The Role of Augmented Feedback

Published on: June 19, 2016

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アクション抑制は,ストライタル回路経由で対戦相手の並列制御を明らかにします.

Bruno F Cruz1, Gonçalo Guiomar1, Sofia Soares1,2

  • 1Champalimaud Neuroscience Programme, Champalimaud Research, Champalimaud Foundation, Lisbon, PT, Portugal.

Nature
|July 6, 2022
PubMed
まとめ

ベースリンパ節

さらに関連する動画

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

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Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

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関連する実験動画

Last Updated: Sep 5, 2025

Force and Position Control in Humans - The Role of Augmented Feedback
06:31

Force and Position Control in Humans - The Role of Augmented Feedback

Published on: June 19, 2016

8.0K
Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

9.3K
Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
09:48

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

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科学分野:

  • 神経科学
  • 計算神経科学
  • モーター コントロール

背景:

  • ベースリンパ節の直接的・間接的経路は,従来,それぞれ促進・抑制作用と見なされてきた.
  • ストライタル直接および間接的な中等脊髄ニューロン (dMSNおよびiMSN) の共活性化は,この古典的なモデルに異議を唱える.
  • 基礎性腺の機能を理解することは,行動の開始と抑制を説明するために不可欠です.

研究 の 目的:

  • 行動の促進と抑制における直接的・間接的経路の異なる役割を調査する.
  • アクション抑制中のdMSNとiMSNの機能的対立性を探求する.
  • 行動制御に寄与する地域特有の基礎状回路を明らかにする.

主な方法:

  • インターバル分類タスクを実行するマウスのベースガンリア回路を研究した.
  • 繊維光度測定と 電気生理学的記録を用いた.
  • オプトジェネティック阻害と 計算による強化学習モデルを使用した.

主要な成果:

  • 背側線状体 (DLS) の作用抑制中に観察されたdMSNとiMSNの機能的対抗性.
  • DLSの回路は 活性化するのではなく 抑制していることがわかりました
  • iMSNは逆行作用を抑制し,dMSNは背中線状体でそれを促進することが示された.

結論:

  • ベースガンリア回路と領域の間の対極的な相互作用により 行動制御が可能になります
  • 感覚運動の間接的な経路は 誘惑の行動を 積極的に抑制する上で 重要な役割を果たします
  • ストレータル回路は,運動制御において地域特有の機能を示す.