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Updated: Sep 5, 2025

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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細胞-マトリックスインターフェースは,ヒトの大腸がん幹細胞の休眠状態を調節する

Yuki Ohta1, Masayuki Fujii1, Sirirat Takahashi1

  • 1Department of Organoid Medicine, Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan.

Nature
|July 7, 2022
PubMed
まとめ

癌幹細胞 (CSCs) は,化学療法後に再発を引き起こす可能性があります. 休眠状態を維持するp27とCOL17A1を発現するLGR5+CSCを特定しました. YAPシグナル伝達を阻害すると,CSCが休眠状態から抜け出すのを阻害することで再発を防ぐことができます.

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