関連する実験動画

Updated: Sep 4, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

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偏ったGタンパク質結合受容体におけるβ-アレスティンの採用を誘導するコンフォメーション選択

Andrew B Kleist1,2, Shawn Jenjak1, Andrija Sente3

  • 1Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Science (New York, N.Y.)
|July 20, 2022
PubMed
まとめ

Gタンパク質結合受容体 (GPCRs) は,非典型のケモカイン受容体 (ACKRs) のようにβ-アレスティンを誘発する. この研究では,ACKR3の構成動態がβ-アレスティン結合の鍵であり,バイアスなGPCRシグナル伝達に関する洞察を提供します.

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