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Updated: Sep 4, 2025

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人間の癌細胞におけるAPOBEC3変異のメカニズム

Mia Petljak1, Alexandra Dananberg2, Kevan Chu2

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA. mpetljak@broadinstitute.org.

Nature
|July 21, 2022
PubMed
まとめ

内生APOBEC3酵素は癌の変異を誘導する. APOBEC3Aを削除すると,シグネチャが減少し,APOBEC3Bを削除すると,APOBEC3Aの活性が増加し,重要な突然変異のメカニズムが明らかになりました.

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