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Updated: Sep 4, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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ADAR1はZBP1による致命的なタイプIインターフェロン誘導を回避する

Huipeng Jiao1,2, Laurens Wachsmuth1,2, Simone Wolf1,2

  • 1Institute for Genetics, University of Cologne, Cologne, Germany.

Nature
|July 21, 2022
PubMed
まとめ

ADAR1は通常,Z- RNAと結合することで有害なタイプIインターフェロン反応を防ぐ. ZBP1が存在しないと,これらの反応が活性化し,病気を引き起こします. ZBP1欠乏症は,機能的なADAR1が欠けているマウスを保護します.

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