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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

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C-C σ-結合の酸化添加とマクロサイクルサポートされた二鉄複合体による水素機能化

Tianchang Liu1, Ryan P Murphy1, Patrick J Carroll1

  • 1Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Journal of the American Chemical Society
|July 26, 2022
PubMed
まとめ

この研究は,二鉄複合体を用いてC−C結合活性化のための新しい無助酸化加減反応を実証した. これらの発見は,触媒サイクルを通じて効率的なC−C結合機能を可能にします.

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Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
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