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Updated: Sep 3, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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ボリル・ディクテッド・サイト・セレクティブ・インターモレキュラー・アリル・プロパルギル・C-H・アミネーション

Yuan Liu1, Zhi-Hao Chen1, Yin Li1

  • 1School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou510006, China.

Journal of the American Chemical Society
|July 27, 2022
PubMed
まとめ

この研究では,α-アミノボロナートを生成するための新しいボリル誘導C-Hアミナート法が導入されています. ボロ酸塩 (B(MIDA) は,高度にサイト選択的な機能化を可能にし,アリルC-H活性化における以前の課題を克服した.

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