皮質フィードバックループは,作業メモリの分散表現を結合する
Ivan Voitov1,2, Thomas D Mrsic-Flogel3
1Sainsbury Wellcome Centre, University College London, London, UK. i.voitov@ucl.ac.uk.
Nature
|July 27, 2022
まとめ
ニューラル回路は 視覚的作業記憶を維持します 視覚領域AMと前運動領域M2の 相互接続した皮質領域における 高次元の活動は この認知機能にとって極めて重要です
科学分野:
- 神経科学
- 認知科学
背景:
- 作業記憶は 柔軟な行動に不可欠ですが その神経表現と維持メカニズムは 完全に理解されていません
- 以前の研究では 脳の様々な領域で 作業記憶に関連した活動が観察されましたが 精密なニューラル集団表現は 捉え難いままです
研究 の 目的:
- ネズミの視覚作業記憶の ニューラル実装を調査する
- 作業記憶の表現の維持に関与する特定の脳領域と集団活動ダイナミクスを特定する.
主な方法:
- マウスは遅延した非マッチ・トゥ・サンプルのタスク (作業記憶を必要とする) と差別タスク (作業記憶を必要としない) を実行した.
- 特定の皮質領域の神経活動を選択的に妨害するために,一時的な光遺伝的不活性化が使用されました.
- 作業記憶の神経関連性を特定するために,集団の活動を記録し,分析した.
主要な成果:
- 視覚領域AMと前運動領域M2を含む分布した新皮質領域は,選択的に作業記憶の維持に必要なものでした.
- 作業記憶の表現は,遅延期間に観察された低次元のダイナミクスとは異なる高次元の集団活動で発見されました.
- 作業メモリに不可欠な,AMまたはM2の通信を停止する.
結論:
- 相互に繋がった皮質領域は 視覚的な作業記憶に 重要な高次元の表現を保持します
- この発見は,作業記憶のような認知機能をサポートする 分散した皮質ネットワークとそのコミュニケーションの役割を強調しています.
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