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Updated: Sep 3, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
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Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

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ケトゲネシスの障害は,COVID-19におけるT細胞機能不全と代謝を結びつける

Fotios Karagiannis1, Konrad Peukert2, Laura Surace1,2

  • 1Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Nature
|July 28, 2022
PubMed
まとめ

ケトゲネシスは,肺感染症におけるT細胞機能に不可欠なβ-ヒドロキシブチラート (BHB) を生成します. 重度のCOVID-19でBHBの生産が低下すると,免疫反応が阻害されるが,BHBの補給はT細胞の機能を回復し,死亡率を低下させる.

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