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Updated: Sep 2, 2025

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

Published on: January 9, 2019

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コロナウイルスは宿主システイン-アスパルティックプロテアスを利用して複製する

Hin Chu1,2,3,4, Yuxin Hou5, Dong Yang5

  • 1State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, China. hinchu@hku.hk.

Nature
|August 3, 2022
PubMed
まとめ

コロナウイルスは宿主アポトーシス経路を利用し,カスパース-6を用いてウイルスのタンパク質を割ります. このプロセスは免疫反応を阻害し,ウイルスの複製と病原性を強化する断片を生成します.

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