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Updated: Sep 2, 2025

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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主要なSARS-CoV-2キラーT細胞エピトープにおける免疫脱出の出現

Garry Dolton1, Cristina Rius1, Md Samiul Hasan1

  • 1Division of Infection and Immunity, Cardiff University School of Medicine, CF14 4XN Cardiff, Wales, UK.

Cell
|August 5, 2022
PubMed
まとめ

一般的なSARS-CoV-2のT細胞エピトープ変異 (Spike P272L) は,頻繁に発生するHLA A*02型の個体において,T細胞による認識を回避した. これは,スパイクタンパク質のみを標的としたワクチンのウイルスの脱出の可能性を強調しています.

キーワード:
CD8 T細胞コロナウイルスSARS-CoV-2についてT細胞T細胞受容体免疫脱出ペプチドHLA系統遺伝学

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