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Updated: Sep 2, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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カルベンの等価物としてスルフォンを用いた孤児サイクロプロパンの効率的な合成

John Douglas Johnson1, Charles Reece Teeples1, Nicholas Rajai Akkawi1

  • 1Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States.

Journal of the American Chemical Society
|August 8, 2022
PubMed
まとめ

この研究は,硫酸アニオンを用いて重要な天然製品である1,1-ダイアルキルcyclopropanesを合成するための新しい方法を導入しています. このアプローチは,金属触媒カルベンの移転の限界を克服し,効率的なサイクロプロパン形成を可能にします.

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