Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration02:34

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

8.6K
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
8.6K
Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

3.1K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
3.1K
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement01:21

[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

2.8K
The Cope rearrangement is classified as a [3,3] sigmatropic shift in 1,5-dienes, leading to a more stable, isomeric 1,5-diene. The reaction involves a concerted movement of six electrons, four from two π bonds and two from a σ bond, via an energetically favorable chair-like transition state.
2.8K
RNA Editing02:23

RNA Editing

9.1K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.1K
Regioselectivity and Stereochemistry of Hydroboration02:36

Regioselectivity and Stereochemistry of Hydroboration

8.4K
A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn...
8.4K
Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

12.8K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
12.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Highly Selective and Modular Assembly of Densely Substituted Tetrahydrofurans.

Journal of the American Chemical Society·2026
Same author

Reactions of Strained Cycloalkanes with Radicals and Diradicaloids: The Roles of Diradical Character and Strain Release.

Journal of the American Chemical Society·2026
Same author

MLAC: MicroED-assisted ligand structure analysis in complexes and its application to hERG-ligand complexes.

Journal of structural biology·2026
Same author

Stereoselective C1-Arylation of Native Sugars via Ligand-Promoted Nickel Catalysis.

Journal of the American Chemical Society·2026
Same author

Conformation-driven C3-C(<i>sp</i> <sup>3</sup>)-H arylation of saturated azacycles using Pd catalyst.

Nature catalysis·2026
Same author

Determining Quantum Mechanical Methods Suitable for Quantitative Modeling of Hydrogen Atom Transfer by Halogen Atoms.

Journal of chemical theory and computation·2026

関連する実験動画

Updated: Sep 2, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

24.7K

距離,幾何学,キラリティによるアザアレンC-H結合の分子編集

Zhoulong Fan1, Xiangyang Chen2, Keita Tanaka1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

Nature
|August 9, 2022
PubMed
まとめ

この研究は,バイサイクルアザアリーナにおける選択的な炭素-水素 (C-H) 結合機能化のための新しい指向テンプレートを導入する. これらのテンプレートは,複雑な医薬品の分子編集を可能にします.

さらに関連する動画

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
04:38

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Published on: July 28, 2022

3.1K
Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

8.5K

関連する実験動画

Last Updated: Sep 2, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

24.7K
Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
04:38

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Published on: July 28, 2022

3.1K
Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

8.5K

科学分野:

  • 有機化学
  • 薬剤化学
  • 合成化学

背景:

  • 炭素-水素 (C-H) 結合の直接的な分子編集は,医薬品化学にとって不可欠な多様な化学空間への迅速なアクセスを提供します.
  • 遠隔C−H結合は,固有のステリックまたは電子バイアスが欠如しているため,選択的に機能化することが困難である.
  • 既存の方法は,これらの複雑な基板上で位置的に類似したC−H結合を区別するのに苦労しています.

研究 の 目的:

  • 遠隔C−H結合の選択的機能化のための新しい指向テンプレートを開発する.
  • 隣接し,位置的に類似したC−H結合のモジュール分化と機能化を可能にする.
  • バイサイクルアザアレンのための統一された後期分子編集戦略を確立する.

主な方法:

  • 2つの異なる指示テンプレートの設計と適用
  • 模板の距離,幾何学,キラリティの調節により,場所の選択性が得られます.
  • キノリン誘導体に対する直接的なC−Hオレフィネーション,アルキニレーション,およびアリレーション反応.

主要な成果:

  • 隣接する遠隔 (C6/C7) および位置的に類似した (C3/C7) C-H結合の二輪性アザアリーナでの成功的な微分化と機能化.
  • キノリンを含む薬剤体のサイト選択的,反復的,および後期C-H編集の実証.
  • 調整された合成アプリケーションのための様々な順序で反応のモジュール実行.

結論:

  • 開発された誘導テンプレートは,挑戦的なサイクルアザアレンシステムの選択的なC-H機能化のための強力な戦略を提供します.
  • このアプローチは 薬物の発見を加速する 遅い段階の分子編集の能力を 大きく高めています
  • 統一された戦略は,任意の場所および任意のシーケンスで,バイサイクルアザレンの正確な変更を可能にします.