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Updated: Sep 2, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
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ヒトリンパ球における多様な変異の風景

Heather E Machado1, Emily Mitchell1,2, Nina F Øbro2,3,4

  • 1Wellcome Sanger Institute, Hinxton, UK.

Nature
|August 10, 2022
PubMed
まとめ

正常なリンパ球は,分化および免疫反応の間にプログラムされたおよび対象外なゲノム変化のために,幹細胞よりも多くの変異を蓄積する. 健康なB細胞の変異パターンは,B細胞がんの変異パターンに似ています.

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