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関連する概念動画

Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Layers of the Heart Wall01:15

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Chambers of the Heart01:16

Chambers of the Heart

The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Anatomy of the Heart01:20

Anatomy of the Heart

The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...

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Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
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人間の心筋梗塞の空間的マルチオームマップ

Christoph Kuppe1,2, Ricardo O Ramirez Flores3,4, Zhijian Li5,6

  • 1Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Nature
|August 10, 2022
PubMed
まとめ
この要約は機械生成です。

この研究では,高解像度で心筋梗塞 (心臓発作) の後の心臓の再構成をマッピングしています. 疾患特有の細胞状態や 分子変化を明らかにし 心臓病の理解と治療の新たな基準を提示しています

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科学分野:

  • 心血管生物学
  • ゲノミクス
  • システム生物学

背景:

  • 心筋梗塞 (心臓発作) は世界の主要な死因です.
  • 現在の治療法は 心臓発作後の 心臓再形成の理解が不十分です
  • 末期の死亡率を減らすには これらの再構築過程の より深い洞察が必要です

研究 の 目的:

  • 心筋梗塞の後の 人間の心臓の再構成の 高解像度分子マップを作成します
  • 細胞と分子の変化を包括的に理解するために,マルチモダルのデータを統合する.
  • 疾患特有の心臓細胞状態とその空間的相互作用を特定する.

主な方法:

  • 単細胞遺伝子発現プロファイリング
  • クロマチンアクセシビリティアッセイ
  • 空間トランスクリプトミックのプロファイリング
  • マルチモダルのデータ統合

主要な成果:

  • 心筋梗塞後の心臓の整合図を作成した.
  • 特定され,検証された疾患特有の心臓細胞状態は,異なる組織ゾーンと時間点で.
  • 心臓組織組織の解明された分子原理, 心筋細胞と骨髄連続体の傷害後の構造.
  • 心臓のトランスクリプトームとエピジェノームの変化を明らかにし 損傷,修復,再構築の構造を明らかにしました

結論:

  • この研究は,ヒトの心筋梗塞の重要な分子参照地図を提供します.
  • この発見は,疾患中の心臓細胞の空間的な文脈と相互依存性についての洞察を提供します.
  • この研究は,心臓病の高度なメカニズム研究と新しい治療戦略の基礎をなしています.