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Updated: Sep 1, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.9K

エピジェネティックリーダSP140 制御不能のマクロファージトポイソメラーゼによる機能喪失がクローン病を誘発する

Hajera Amatullah1, Isabella Fraschilla2, Sreehaas Digumarthi3

  • 1Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.

Cell
|August 11, 2022
PubMed
まとめ

斑点タンパク質140 (SP140) の喪失は,トポイソメラーゼの活性を解き放つことで免疫機能障害を引き起こす. トポイソメラーゼ (TOPs) を阻害することで,これらの欠陥を修復し,SP140に関連する疾患に対する潜在的な治療法を提供します.

キーワード:
クローン病博士号SP140 について斑点状のタンパク質ブロモドメインクロマチンエピジェネティック・リーダー炎症性腸疾患マクロファージトポイソメラーゼ

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Chronic Salmonella Infection Induced Intestinal Fibrosis

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