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Updated: Sep 1, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

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機能的調節変異は,認知症における異なる転写ネットワークを伴う

Yonatan A Cooper1,2,3, Noam Teyssier4, Nina M Dräger4

  • 1Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Science (New York, N.Y.)
|August 18, 2022
PubMed
まとめ

アルツハイマー病 (AD) と進行性超核性麻痺 (PSP) の機能的変異を特定することが重要です. この研究では,遺伝子ネットワークに影響を与える 320の機能的調節変種 (frVars) が発見され,神経変性疾患の遺伝学に関する理解を深めました.

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