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Updated: Aug 31, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
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塩素媒介アルケンの活性化は,エナチオセレクティブチオウレアと塩素共触媒プリンのサイクルを誘発する

Dennis A Kutateladze1, Corin C Wagen1, Eric N Jacobsen1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|August 22, 2022
PubMed
まとめ

チラルチオウレア触媒は,新しいアルケンの活性化メカニズムを通じて,エナチオセレクティブのプリンスサイクルを可能にします. このプロセスは,塩化水素 (HCl) と水素結合ドナー (HBD) コンプレックスを含み,塩化水素媒介の基板活性化により選択性が向上します.

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