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Updated: Aug 31, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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産前リポポリサッカライドの暴露は,高血圧の世代間遺伝を誘発する

Nian Cao1,2,3, Cong Lan1,2, Caiyu Chen1,2

  • 1Department of Cardiology, Daping Hospital (N.C., C.L., C.C., Z.X., H.L., S.Z., X.G., H.R., Z.L., S.Q., C.Y., G.W., C.H., J.Yu, C.Z.), The Third Military Medical University (Army Medical University), P.R. China.

Circulation
|August 25, 2022
PubMed
まとめ

Lipopolysaccharide (LPS) に対する不良な産前暴露は,表遺伝的変化によって複数の世代に渡って高血圧を引き起こす可能性があります. 反応性酸素種のスキャベンジャーは この世代を超えた高血圧を予防し 潜在的な治療戦略を提供しました

キーワード:
エピジェネティクス高血圧リポポリサッカライド反応性酸素種ミネラルコルチコイド受容体

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