脂肪組織の体感覚内置の役割

Yu Wang^1,2, Verina H Leung¹, Yunxiao Zhang^1,2

¹Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.

Nature

|August 31, 2022

まとめ

脂肪組織にある感覚神経は交感系のブレーキとして働きエネルギーバランスに影響しますこれらの神経を切断すると脂肪パッドが大きくなり体温が上昇します

科学分野:

神経科学
メタボリズム
脂肪組織生物学

背景:

脂肪組織はエネルギーホメオスタシスのために中枢神経系と通信します
循環ホルモンと交感出力は研究された主な経路です.
脂肪組織を神経化する感覚神経細胞の役割は,遺伝的ツールが限られているため,十分に理解されていません.

研究の目的:

脂肪組織における感覚神経を操作するための遺伝的ツールを開発し利用する.
背骨の根のガンジア (DRG) の脂肪内置の生理学的役割を解明する.
脂肪組織における感覚神経と交感機能の相互作用を理解する.

主な方法:

マウスの感覚神経の器官特有の操作のためのウイルス,遺伝子,画像戦略の開発.
皮膚下の脂肪細胞へのDRGの軸突投影の可視化
脂肪組織における選択的感覚剥離と,その結果生じる現象型の評価.

主要な成果:

脂肪組織における感覚内置の解剖学的視覚化が確立された.
セレクティブ・センサリー・アブレーションはリポジェニックとサーモジェネティック・プログラムを強化した
感覚の消去により脂肪パッドが大きくなりベージュ色の脂肪細胞が増加し体温が上昇しました

結論:

脂肪組織にある感覚神経は交感系にブレーキをかける.
DRGの内置は脂肪細胞の機能とエネルギーホメオスタシスの調節に重要な役割を果たします.
これらの発見は,感覚内包を研究するための新しい道を開きます.

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