振動器の回路を引っ張る

Jun Takatoh^1,2, Vincent Prevosto^3,4, P M Thompson^3,5

¹Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. jtakatoh@mit.edu.

Nature

|August 31, 2022

まとめ

研究者達はネズミのリズムを制御する神経回路を特定しましたこの回路は脳幹の阻害性ニューロンを構成し,リズム運動パターンの生成における再発阻害の重要な役割を果たしています.

科学分野:

神経科学
モーターコントロール
計算神経科学

背景:

中央振動器はリズム運動のための基本的な神経回路です
これらの回路を理解するには特定のニューロンとその接続を特定する必要があります
研究のために哺乳類の神経回路をターゲットにすることは依然として困難です.

研究の目的:

ネズミの神経回路を特定する
ウィスキングリズム生成の基礎となる細胞とネットワークのメカニズムを解明する.

主な方法:

オシレータニューロンの遺伝子識別
目覚めたマウスの電気生理学的記録
オプトジェネティック操作と特定のニューロン集団の静止
オプトタグされたニューロンの体内記録

主要な成果:

振動器は脳幹にあるパルバルブミン発現抑制ニューロン (vIRtPV) を含む.
vIRtPVのニューロンは休息状態で発火し発火時に発火する.
vIRtPVニューロンを静止させると振動が停止し阻害的インプットを消去するとリズム生成が妨げられます
vIRtPVニューロンの間の再発性抑制結合はリズム発生に不可欠です.

結論:

振動器は完全に阻害的なネットワークです
vIRtPVネットワーク内の再発性シナプス阻害は,ウィスキングリズムを生成するために不可欠です.
ネットワークのダイナミクスは細胞の内在的な性質よりも動きのリズムを生成する要因です

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