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Updated: Aug 30, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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セロトナージック・アクソン・シリウム・シナプスは,クロマチンのアクセシビリティを変化させる核信号を駆動する

Shu-Hsien Sheu1, Srigokul Upadhyayula2, Vincent Dupuy3

  • 1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Department of Pathology, Boston, MA, USA; Howard Huges Medical Institute, Boston Children's Hospital, Department of Cardiology, Boston, MA, USA.

Cell
|September 2, 2022
PubMed
まとめ

研究者らは,軸索が放出するセロトニンが神経細胞のプライマリシリアに直接影響する新しい軸索シリアシナプスを発見しました. この経路はクロマチンのアクセシビリティを調節することで遺伝子発現を変化させ,神経細胞の伝達と表遺伝的調節に関する新しい洞察を提供します.

キーワード:
FIB-SEMGPCRシグナリングクロマチンのアクセシビリティ光寿命イメージングヒストンの改変核アクチン主要なニキビピラミッド型ニューロンセロトニン

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