脳幹ADCYAP1+ニューロンは,病気の行動の複数の側面を制御する
Anoj Ilanges1, Rani Shiao1, Jordan Shaked1
1Laboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
Nature
|September 7, 2022
まとめ
研究者たちは 細菌の内毒素によって引き起こされる 病気の行動を制御する 特定の脳幹ニューロンを特定しました これらのニューロンを活性化すると 病気の反応が複製され 抑制すると これらの効果が減り 脳と感染症の 重要な関係が明らかになります
科学分野:
- 神経科学
- 免疫学
- 行動科学
背景:
- 感染症は アノレキシアや麻痺といった 適応性疾患を誘発します
- これらの病気反応の基礎となる 神経機構はほとんど不明である.
研究 の 目的:
- 病気の行動を制御する 特定の神経集団を特定するためです
- 感染に対する様々な反応を 司る脳の役割を解明するためです
主な方法:
- LPS治療後のFOS発現を用いた全脳活動マッピング
- 特定のニューロンを再活性化するための遺伝子操作 (TRAP2マウス)
- ニューラル集団を特定するための単核RNA配列解析
- 行動への影響を評価するために 神経活動の抑制
主要な成果:
- LPS治療は,単一管 (NTS) の核と領域前膜 (AP) の特定のニューロンを活性化しました.
- これらのNTS-APニューロンの再活性化は 病気の行動や発熱を模倣しました
- これらのニューロンの抑制により,LPSによって引き起こされるすべての病気の行動が減少しました.
- NTS-APで完全に再現されたLPS効果におけるADCYAP1+ニューロンの活性化.
結論:
- 特定のNTS-APニューラル集団は,病気への反応のために必要であり,十分である.
- この研究は 脳の機能と 宿主の感染反応の間の 重要な関係を確立しています
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