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Updated: Aug 29, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes

Published on: March 14, 2021

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フォスフォノシチドシグナル伝達経路は,迅速なリゾソーム修復を媒介する

Jay Xiaojun Tan1,2, Toren Finkel3,4

  • 1Aging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. jay.tan@pitt.edu.

Nature
|September 7, 2022
PubMed
まとめ

リンソーム膜浸透 (LMP) は,脂質輸送を含む修復経路を誘発する. このフォスフォノシチド誘発性膜結合 (PITT) 経路は,年齢関連の疾患の予防に不可欠なリンソームの完全性を迅速に回復させます.

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Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
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Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
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