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Updated: Aug 29, 2025

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System
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Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System

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ABP1-TMKオクシン感知 グローバルリン酸化とオクシンチャネライゼーション

Jiří Friml1, Michelle Gallei2, Zuzana Gelová2

  • 1Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria. jiri.friml@ista.ac.at.

Nature
|September 7, 2022
PubMed
まとめ

植物ホルモンであるオクシン

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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