トランスラトームとトランスクリプトームの共同プロファイリングは,ヒトジゴティックゲノム活性化におけるTPRXの役割を明らかにする

Zhuoning Zou1,2,3, Chuanxin Zhang4,5,6,7,8, Qiuyan Wang1,2

  • 1Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Science (New York, N.Y.)
|September 8, 2022
PubMed
まとめ

この研究では,初期発達の時のヒトジゴティックゲノム活性化 (ZGA) の重要なトランスレーションレギュレータを明らかにした. PRDのようなホメオボックス転写因子は,ZGAと胚の発達にとって極めて重要です.

関連する概念動画

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K
Prokaryotic Transcriptional Activators and Repressors01:58

Prokaryotic Transcriptional Activators and Repressors

8.6K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.5K
tRNA Activation02:26

tRNA Activation

6.9K
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
77
Master Transcription Regulators02:23

Master Transcription Regulators

2.3K