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Updated: Aug 29, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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サイクロプロパン-融合N-ヘテロサイクルは,アザ-ヘック-トリガードC ((sp3) -H機能化カスケード経由で

Changcheng Jing1, Benjamin T Jones2, Ross J Adams1

  • 1Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom.

Journal of the American Chemical Society
|September 9, 2022
PubMed
まとめ

この研究は,C ((sp3) -H機能化のための新しいアザ-ヘック反応を導入し,パラジウム触媒を介してサイクロプロパンを生成します. 研究は,様々な融合システムにおける場所の選択性を制御する要因を詳細に述べています.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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