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Updated: Aug 28, 2025

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

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mTOR調節されたミトコンドリア代謝は,ミコバクテリア誘発の細胞毒性を制限する

Antonio J Pagán1, Lauren J Lee2, Joy Edwards-Hicks3

  • 1Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Cell
|September 14, 2022
PubMed
まとめ

結核耐性はマクロファージの代謝に関係している. mTORキナーゼ経路は,ESAT-6のようなミコバクテリアの毒素による損傷を防ぐために,エネルギー代謝を刺激することによって,マクロファージを死から保護します.

キーワード:
ESAT-6 ミト毒性ミコバクテリア・マリニウムミコバクテリア 結核グラヌロマ・ネクロスmTOR についてマクロファージ死亡ミトコンドリアの代謝酸化性リン酸化結核ゼブラフィッシュTBモデル

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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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