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Updated: Aug 28, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
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[3.1.1]プロペランからメタ置換されたアレンバイオイソステルの合成

Nils Frank1, Jeremy Nugent1, Bethany R Shire1

  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.

Nature
|September 15, 2022
PubMed
まとめ

研究者は,薬剤設計のための新しいメタアレンバイオイソステルとして,ビサイクロ[3.1.1]ヘプタン (BCHeps) を開発した. これらのsp3豊富なモチーフは,伝統的なベンゼンリングと比較して,代謝の安定性と溶解性を改善します.

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