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Updated: Aug 28, 2025

Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein Expressed in Saccharomyces cerevisiae
15:12

Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein Expressed in Saccharomyces cerevisiae

Published on: May 10, 2014

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ヒトシスティンエクスポーターシスティノシンの構造とメカニズム

Xue Guo1, Philip Schmiege2, Tufa E Assafa3

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|September 16, 2022
PubMed
まとめ

研究者らは,リソソムのアミノ酸流出の鍵となるトランスポーターであるシスティノシンの構造を明らかにした. この発見はシスティンの輸出メカニズムを明らかにし,リソソムの蓄積病であるシスティノシスに対する潜在的な治療戦略を提供します.

キーワード:
DEER (鹿) についてキーワードラグレーター-ラグ複合体X線結晶学クリオ・エムシスティノシンシスティノシス迅速に適応するリンソーム貯蔵病リンソームトランスポーター膜タンパク質の動態

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Author Spotlight: Functional Site-Directed Fluorometry in Native Cells to Study Skeletal Muscle Excitability12:26

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In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
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NES are of three types- the canonical 10-residue long leucine-rich signal and other...
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One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
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