シルカディアンリズムと睡眠時間の障害
Nicholas Meyer1, Allison G Harvey2, Steven W Lockley3
1Insomnia and Behavioural Sleep Medicine Clinic, University College London Hospitals NHS Foundation Trust, London, UK; Department of Psychosis Studies, Institute of Psychology, Psychiatry, and Neuroscience, King's College London, London, UK.
Lancet (London, England)
|September 17, 2022
まとめ
昼夜リズムが 睡眠と覚醒のサイクルを調整しますが 現代生活では この調整が妨げられ 睡眠障害が生じます 新しい技術はこれらのタイミングの問題の診断と治療を改善する可能性があります.
科学分野:
- クロノバイオロジー
- 睡眠科学
- 神経科学
背景:
- 日常の睡眠と覚醒のサイクルは 24時間の内在的な生理リズムによって支配されます
- 分子振動器によって生成される これらのリズムは 睡眠と環境の夜間に合わせていますが 現代的なライフスタイルに 影響されやすいのです
- 睡眠時間の乱れや 身体的健康や 精神的健康に影響し 昼夜リズムに障害が生じます
研究 の 目的:
- サーカディアンリズム障害の現在のカテゴリーを批判的に検討する.
- これらの障害の発達における サーカディアン・システムの役割を調査する.
- 昼夜リズム,睡眠ホメオスタシス,行動/環境要因の相互作用を調査する.
主な方法:
- 既存の昼夜リズム障害の分類のレビューと批判的検討
- 昼夜リズムと睡眠ホメオスタシスの相互作用を理解するための次元的アプローチ.
- 睡眠と昼間の生理学を定量化するための新興技術 (ウェアラブル,トランスクリプトミクス,数学モデル) の評価.
主要な成果:
- 日常のリズムが全て 乱れているのは サーカディアンリズムが 乱れているからではありません
- シルカディアンリズム,睡眠ホメオスタシス,行動/環境要因が動的に相互作用します.
- 客観的なツールの不足は 睡眠時間の障害の認識と治療を妨げています
結論:
- 昼夜リズム障害の既存のカテゴリーは 批判的に検討する必要がある.
- 睡眠時間の障害を理解するには より広範で次元的なアプローチが必要です
- 新興技術は 睡眠と昼夜科学の進歩に 期待を寄せています
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