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関連する概念動画

Cross-bridge Cycle01:26

Cross-bridge Cycle

118.1K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

677
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
677
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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関連する実験動画

Updated: Aug 28, 2025

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

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アミオトロフィック・ラテラル・スクレロス

Eva L Feldman1, Stephen A Goutman1, Susanne Petri2

  • 1Department of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

Lancet (London, England)
|September 18, 2022
PubMed
まとめ

アミオトロフィック横筋硬化症 (ALS) の管理は 新しい診断基準と 複雑な性質の理解によって改善されています 病理生理学の進歩や バイオマーカーや治療法により 患者の改善が期待できます

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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

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Last Updated: Aug 28, 2025

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS
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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

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科学分野:

  • 神経科学
  • 神経科学

背景:

  • アミオトロフィック横筋硬化症 (ALS) は致命的な中枢神経系 (CNS) 神経退行性疾患で,現在の管理は最適ではない.
  • フェノタイプの異質性と全局的な中枢神経機能障害はALSの特徴であり,診断と予後アプローチの改善が必要である.

研究 の 目的:

  • ALSの病理生理学,診断,予後に関する最近の洞察を概説します.
  • 神経学者のための ALS 管理の現状と将来の見通しについて議論する.

主な方法:

  • ALSの異質性,遺伝学,病理生理学に関する現在の研究のレビュー.
  • 新しい診断基準,バイオマーカー,リスク要因,予測モデルの分析
  • メカニズムベースの治療法の臨床試験パイプラインの検討

主要な成果:

  • ALSを複雑な症候群として認識することは,臨床実務に影響を与えている.
  • ALSの解明の進歩は そのスペクトルを解明し 診断を容易にしています
  • 新しい洞察が 予後を変化させていますが 患者の利益は待っています

結論:

  • 課題があるにもかかわらず 新興の研究はALSの臨床上 具体的な効果をもたらしています
  • 将来の見通しには 動脈縮性側頭葉硬化症の患者のケアと 結果の改善が含まれます
  • ALSの病理生理学と治療法の継続的な研究は 臨床的進歩に不可欠です