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Updated: Aug 28, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

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受容体分解のためのE3ユビキチンリガゼの抗体標的化

Hadir Marei1, Wen-Ting K Tsai2, Yee-Seir Kee2

  • 1Discovery Oncology, Genentech, South San Francisco, CA, USA.

Nature
|September 21, 2022
PubMed
まとめ

研究者は細胞表面のタンパク質を分解する タンパク質分解標的抗体 (PROTAB) を開発しました この新しい方法は 標的型タンパク質分解の 強力で選択的なアプローチで 伝統的な抑制療法の限界を克服します

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