耐久性アフィニティの成熟とクローン移動を持つ長プリム生殖センター

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Updated: Aug 28, 2025

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

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Jeong Hyun Lee1,2,3, Henry J Sutton1,2, Christopher A Cottrell2,3,4

  • 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

Nature
|September 21, 2022
PubMed
まとめ

長期生殖中心のB細胞 (BGC) は,最初の免疫接種後6ヶ月以上持続し,抗体の継続的な進化を示し,増強後に高チーターの中和抗体につながった. この長期的予防接種戦略は 難しいワクチンのターゲットに 利益をもたらします

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Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers10:07

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