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Updated: Aug 27, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Published on: February 6, 2019

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ファルマコフォア指向のレトロ合成戦略を用いたラメスワライドの総合成

Nathanyal J Truax1, Safiat Ayinde2, Jun O Liu2

  • 1Department of Chemistry & Biochemistry, Baylor University, 101 Bagby Avenue, Waco, Texas 76710, United States.

Journal of the American Chemical Society
|September 27, 2022
PubMed
まとめ

ラメスワラリドの最初の完全合成は,薬剤指向戦略を用いて達成された. このアプローチにより,構造と作用の関係が確立され,強力な抗がん作用を持つ重要な中間物質が特定されました.

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