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Updated: Aug 27, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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DCAF1をステレオセレクティブで局所的に誘導する電子性PROTACによる標的型タンパク質分解

Yongfeng Tao1, David Remillard1, Ekaterina V Vinogradova1

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92307, United States.

Journal of the American Chemical Society
|September 28, 2022
PubMed
まとめ

研究者らは,タンパク質の分解のためにDCAF1を標的とする新しいアゼチジンアクリラミドを発見した. 標的型タンパク質分解のこの突破は,電気愛好性PROTACを用いた化学探査と薬剤発見の新たな道を開きます.

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