関連する実験動画

Updated: Aug 27, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.0K

マクロサイクルペプチドによるヘトロトリメルGαシグナリングのステート選択的調節

Shizhong A Dai1, Qi Hu1, Rong Gao2

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Cell
|September 28, 2022
PubMed
まとめ

研究者らは,Gαsタンパク質を標的とする新しい循環性ペプチド,GN13とGD20を発見した. これらの阻害剤は選択的にGαsの活性を調節し,GTPase関連の疾患に対する新たな治療手段を提供している.

キーワード:
Gタンパク質GIRK についてGTPase についてGαs についてcAMP について化学探査機サイクルペプチド薬物の発見阻害剤タンパク質の結晶構造

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