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Updated: Aug 27, 2025

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

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LRRC15+ミオフィブロブラストは,腫瘍免疫を抑制するストロマのセットポイントを決定する

Akshay T Krishnamurty1, Justin A Shyer1, Minh Thai1

  • 1Genentech, South San Francisco, CA, USA.

Nature
|September 28, 2022
PubMed
まとめ

トランスフォーマーがん治療:TGFβの抑制により,レウシンに富んだリピート含有タンパク質15 (LRRC15) + がん関連フィブロブラストを標的にすることで,抗腫瘍免疫性が強化され,免疫療法の反応が改善される可能性があります.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

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T Cell Types and Functions

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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