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Updated: Aug 27, 2025

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腫瘍代謝物質d-2HGは,T細胞代謝を変化させ,CD8+ T細胞機能を損なう

Giulia Notarangelo1, Jessica B Spinelli1, Elizabeth M Perez2,3,4

  • 1Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Science (New York, N.Y.)
|September 29, 2022
PubMed
まとめ

腫瘍で生成されるd- 2ヒドロキシグルタレットは,乳酸脱水素酶 (LDH) を標的としてCD8+T細胞の抗腫瘍機能を損なう. この代謝再プログラムにより,T細胞の細胞毒性およびインターフェロン-ガンマ信号伝達が低下し,IDH変異性膠原腫に影響を与えます.

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